Učitavanje...
Sequence composition of disordered regions fine-tunes protein half-life
The proteasome controls the concentrations of most proteins in eukaryotic cells. It recognizes its protein substrates through ubiquitin tags and initiates degradation at disordered regions within the substrate. Here we find that the proteasome has pronounced preferences for the amino acid sequence c...
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| Izdano u: | Nat Struct Mol Biol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351145/ https://ncbi.nlm.nih.gov/pubmed/25643324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2958 |
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