Nuclear Import Factor Srp1 and Its Associated Protein Sts1 Couple Ribosome-bound Nascent Polypeptides to Proteasomes for Cotranslational Degradation

Cotranslational protein degradation plays an important role in protein quality control and proteostasis. Although ubiquitylation has been suggested to signal cotranslational degradation of nascent polypeptides, cotranslational ubiquitylation occurs at a low level, suggesting the existence of an alte...

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Bibliographic Details
Main Authors: Ha, Seung-Wook, Ju, Donghong, Xie, Youming
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908403/
https://ncbi.nlm.nih.gov/pubmed/24338021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524926
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