Co-fibrillogenesis of Wild-type and D76N β(2)-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS

The amyloidogenic variant of β(2)-microglobulin, D76N, can readily convert into genuine fibrils under physiological conditions and primes in vitro the fibrillogenesis of the wild-type β(2)-microglobulin. By Fourier transformed infrared spectroscopy, we have demonstrated that the amyloid transformati...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Natalello, Antonino, Mangione, P. Patrizia, Giorgetti, Sofia, Porcari, Riccardo, Marchese, Loredana, Zorzoli, Irene, Relini, Annalisa, Ami, Diletta, Faravelli, Giulia, Valli, Maurizia, Stoppini, Monica, Doglia, Silvia M., Bellotti, Vittorio, Raimondi, Sara
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850305/
https://ncbi.nlm.nih.gov/pubmed/26921323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720573
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