USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock

Mammalian Cryptochromes, CRY1 and CRY2, function as principal regulators of a transcription-translation-based negative feedback loop underlying the mammalian circadian clockwork. An F-box protein, FBXL3, promotes ubiquitination and degradation of CRYs, while FBXL21, the closest paralog of FBXL3, ubi...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Hirano, Arisa, Nakagawa, Tomoki, Yoshitane, Hikari, Oyama, Masaaki, Kozuka-Hata, Hiroko, Lanjakornsiripan, Darin, Fukada, Yoshitaka
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849774/
https://ncbi.nlm.nih.gov/pubmed/27123980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154263
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