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Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein
Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3(-/-)), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3(-/-) mice also exhibited other circadian abnorm...
Gorde:
| Argitaratua izan da: | eLife |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
eLife Sciences Publications, Ltd
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5747517/ https://ncbi.nlm.nih.gov/pubmed/29227248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24779 |
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