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A critical examination of the “bad luck” explanation of cancer risk

Tomasetti and Vogelstein (1) argue that lifetime cancer risk for particular tissues is mostly determined by the total number of stem cell (SC) divisions within the tissue, whereby most cancers arise due to “bad luck” – mutations occurring during DNA replication. We argue that the poorly substantiate...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Rozhok, Andrii I., Wahl, Geoffrey M., DeGregori, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849411/
https://ncbi.nlm.nih.gov/pubmed/26122457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0229
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