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Pooling across cells to normalize single-cell RNA sequencing data with many zero counts
Normalization of single-cell RNA sequencing data is necessary to eliminate cell-specific biases prior to downstream analyses. However, this is not straightforward for noisy single-cell data where many counts are zero. We present a novel approach where expression values are summed across pools of cel...
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| Udgivet i: | Genome Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4848819/ https://ncbi.nlm.nih.gov/pubmed/27122128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0947-7 |
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