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Structural basis of cohesin cleavage by separase

Accurate chromosome segregation requires timely dissolution of chromosome cohesion after chromosomes are properly attached to the mitotic spindle. Separase is absolutely essential for cohesion dissolution in organisms from yeast to man(1,2). It cleaves the kleisin subunit of cohesin and opens the co...

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Pubblicato in:Nature
Autori principali: Lin, Zhonghui, Luo, Xuelian, Yu, Hongtao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847710/
https://ncbi.nlm.nih.gov/pubmed/27027290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17402
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