sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss

sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Haraguchi, Ryuma, Kitazawa, Riko, Mori, Kiyoshi, Tachibana, Ryosuke, Kiyonari, Hiroshi, Imai, Yuuki, Abe, Takaya, Kitazawa, Sohei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846872/
https://ncbi.nlm.nih.gov/pubmed/27117872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25198
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