sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss

sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Haraguchi, Ryuma, Kitazawa, Riko, Mori, Kiyoshi, Tachibana, Ryosuke, Kiyonari, Hiroshi, Imai, Yuuki, Abe, Takaya, Kitazawa, Sohei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846872/
https://ncbi.nlm.nih.gov/pubmed/27117872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25198
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