sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss

sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer...

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Publicat a:Sci Rep
Autors principals: Haraguchi, Ryuma, Kitazawa, Riko, Mori, Kiyoshi, Tachibana, Ryosuke, Kiyonari, Hiroshi, Imai, Yuuki, Abe, Takaya, Kitazawa, Sohei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846872/
https://ncbi.nlm.nih.gov/pubmed/27117872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25198
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