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sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss
sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4846872/ https://ncbi.nlm.nih.gov/pubmed/27117872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25198 |
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