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sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss
sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4846872/ https://ncbi.nlm.nih.gov/pubmed/27117872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25198 |
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