An expanded role for mTORC1 in autophagy

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate o...

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Published in:Mol Cell Oncol
Main Authors: Kim, Young-Mi, Park, Ji-Man, Grunwald, Douglas, Kim, Do-Hyung
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845164/
https://ncbi.nlm.nih.gov/pubmed/27308528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1010958
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