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Structure-guided design of a high affinity inhibitor to human CtBP

Oncogenic transcriptional coregulators C-terminal Binding Protein (CtBP) 1 and 2 possess regulatory D-isomer specific 2-hydroxyacid dehydrogenase (D2-HDH) domains that provide an attractive target for small molecule intervention. Findings that the CtBP substrate 4-methylthio 2-oxobutyric acid (MTOB)...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Hilbert, Brendan J., Morris, Benjamin L., Ellis, Keith C., Paulsen, Janet L., Schiffer, Celia A., Grossman, Steven R., Royer, William E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844192/
https://ncbi.nlm.nih.gov/pubmed/25636004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500820b
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