Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats

[Image: see text] Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptor tyrosine kinase and belongs to the focal adhesion kinase (FAK) family. Like FAK, the C-terminal focal adhesion-targeting (FAT) domain of Pyk2 binds to paxillin, a scaffold protein in focal adhesions; however, the interaction be...

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Udgivet i:Biochemistry
Main Authors: Vanarotti, Murugendra S., Finkelstein, David B., Guibao, Cristina D., Nourse, Amanda, Miller, Darcie J., Zheng, Jie J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843776/
https://ncbi.nlm.nih.gov/pubmed/26866573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01274
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