Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine

BACKGROUND: Cyclic guanosine monophosphate‐protein kinase G‐phosphodiesterase 5 signaling may be disturbed in heart failure (HF) with preserved ejection fraction, contributing to cardiac remodeling and dysfunction. The purpose of this study was to manipulate cyclic guanosine monophosphate signaling...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Hiemstra, Jessica A., Lee, Dong I., Chakir, Khalid, Gutiérrez‐Aguilar, Manuel, Marshall, Kurt D., Zgoda, Pamela J., Cruz Rivera, Noelany, Dozier, Daniel G., Ferguson, Brian S., Heublein, Denise M., Burnett, John C., Scherf, Carolin, Ivey, Jan R., Minervini, Gianmaria, McDonald, Kerry S., Baines, Christopher P., Krenz, Maike, Domeier, Timothy L., Emter, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843537/
https://ncbi.nlm.nih.gov/pubmed/27098966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003277
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