A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini‐swine with compensated heart failure

We recently developed a clinically relevant mini‐swine model of heart failure with preserved ejection fraction (HFpEF), in which diastolic dysfunction was associated with increased mitochondrial permeability transition (MPT). Early diastolic function is ATP and Ca(2+)‐dependent, thus, we hypothesize...

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Bibliographische Detailangaben
Hauptverfasser: Hiemstra, Jessica A., Gutiérrez‐Aguilar, Manuel, Marshall, Kurt D., McCommis, Kyle S., Zgoda, Pamela J., Cruz‐Rivera, Noelany, Jenkins, Nathan T., Krenz, Maike, Domeier, Timothy L., Baines, Christopher P., Emter, Craig A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Periodicals, Inc. 2014
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208639/
https://ncbi.nlm.nih.gov/pubmed/24963034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12050
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