A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini‐swine with compensated heart failure

We recently developed a clinically relevant mini‐swine model of heart failure with preserved ejection fraction (HFpEF), in which diastolic dysfunction was associated with increased mitochondrial permeability transition (MPT). Early diastolic function is ATP and Ca(2+)‐dependent, thus, we hypothesize...

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Autori principali: Hiemstra, Jessica A., Gutiérrez‐Aguilar, Manuel, Marshall, Kurt D., McCommis, Kyle S., Zgoda, Pamela J., Cruz‐Rivera, Noelany, Jenkins, Nathan T., Krenz, Maike, Domeier, Timothy L., Baines, Christopher P., Emter, Craig A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Periodicals, Inc. 2014
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208639/
https://ncbi.nlm.nih.gov/pubmed/24963034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12050
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