Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux

OBJECTIVES: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (K (i) values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis. METHODS: Sildenafil analogues were...

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Detalhes bibliográficos
Publicado no:J Pharm Pharmacol
Main Authors: Subbotina, Anna, Ravna, Aina W., Lysaa, Roy A., Abagyan, Ruben, Bugno, Ryszard, Sager, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Molecular and Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434896/
https://ncbi.nlm.nih.gov/pubmed/28211580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12693
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