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Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
OBJECTIVES: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (K (i) values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis. METHODS: Sildenafil analogues were...
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| Veröffentlicht in: | J Pharm Pharmacol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5434896/ https://ncbi.nlm.nih.gov/pubmed/28211580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12693 |
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