Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux

OBJECTIVES: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (K (i) values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis. METHODS: Sildenafil analogues were...

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Bibliografiska uppgifter
I publikationen:J Pharm Pharmacol
Huvudupphovsmän: Subbotina, Anna, Ravna, Aina W., Lysaa, Roy A., Abagyan, Ruben, Bugno, Ryszard, Sager, Georg
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Molecular and Clinical Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434896/
https://ncbi.nlm.nih.gov/pubmed/28211580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12693
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