Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells

Variability in activity of CYP2C9, which is involved in the metabolism of approximately 15% of current therapeutic drugs, is an important contributor to interindividual differences in drug response. To evaluate the functional alternations of CYP2C9(*)2, CYP2C9(*)3, CYP2C9(*)8, CYP2C9(*)11 and CYP2C9...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Du, Huihui, Wei, Zhiyun, Yan, Yucai, Xiong, Yuyu, Zhang, Xiaoqing, Shen, Lu, Ruan, Yunfeng, Wu, Xi, Xu, Qingqing, He, Lin, Qin, Shengying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843492/
https://ncbi.nlm.nih.gov/pubmed/27199745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00098
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