Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient

Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness. We analyzed the cytochrome P450 2C9 (CYP2C9)...

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Udgivet i:Front Pharmacol
Main Authors: Zhou, Xiao-Yang, Lu, Xiang-Ran, Li, Ying-Hui, Ma, Ya-Qing, Zhao, Shi-Wen, Wang, Fang, Xu, Ren-Ai, Hu, Guo-Xin, Cai, Jian-Ping
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905303/
https://ncbi.nlm.nih.gov/pubmed/33643050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.619339
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