Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro

AIM: Human cytochrome P450 3A4 is the most abundant isoform of P450 enzyme in the liver. It plays an important role in the metabolism of wide variety of xenobiotic and endogenous substrates. So far, there are few reports about the functional characterization of CYP3A4 variants in terms of specific s...

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Foilsithe in:Drug Des Devel Ther
Main Authors: Fang, Ping, Tang, Peng-fei, Xu, Ren-ai, Zheng, Xiang, Wen, Jian, Bao, Su-su, Cai, Jian-ping, Hu, Guo-xin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Dove Medical Press 2017
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Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724423/
https://ncbi.nlm.nih.gov/pubmed/29263648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S152366
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