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Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro
BACKGROUND: Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which in turn contributes to interindividual variability in response to therapeutic drugs. Loperamide, identified as a CYP3A4 substrate, is prone to misuse and abuse and has high risks of life-threatening cardiotoxicity....
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| Publicat a: | Infect Drug Resist |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Dove
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750855/ https://ncbi.nlm.nih.gov/pubmed/31571937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S215129 |
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