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Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro
BACKGROUND: Cytochrome P450 2D6 (CYP2D6), a member of the CYP450 enzyme super family, is a polymorphic enzyme that metabolizes ~25% of therapeutic drugs. CYP2D6 exhibits significant genetic polymorphisms which might cause adverse effects and therapeutic failures of some drugs. OBJECTIVE: The purpose...
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| Veröffentlicht in: | Drug Des Devel Ther |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407444/ https://ncbi.nlm.nih.gov/pubmed/28461741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S133814 |
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