Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization

Development of broadly neutralizing antibodies (bnAbs) against HIV-1 usually requires prolonged infection and induction of Abs with unusual features, such as long heavy-chain complementarity-determining region 3 (HCDR3) loops. Here we sought to determine whether the repertoires of HIV-1–naïve indivi...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Willis, Jordan R., Finn, Jessica A., Briney, Bryan, Sapparapu, Gopal, Singh, Vidisha, King, Hannah, LaBranche, Celia C., Montefiori, David C., Meiler, Jens, Crowe, James E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843476/
https://ncbi.nlm.nih.gov/pubmed/27044078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518405113
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