Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders

Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it overlooks mutations in noncoding regulatory elements. Furthermore, the mechanisms...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Wakabayashi, Aoi, Ulirsch, Jacob C., Ludwig, Leif S., Fiorini, Claudia, Yasuda, Makiko, Choudhuri, Avik, McDonel, Patrick, Zon, Leonard I., Sankaran, Vijay G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843446/
https://ncbi.nlm.nih.gov/pubmed/27044088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521754113
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