Homology-driven genome editing in hematopoietic stem and progenitor cells using zinc finger nuclease mRNA and AAV6 donors

Genome editing with targeted nucleases and DNA donor templates homologous to the break site has proven challenging in human hematopoietic stem and progenitor cells (HSPCs), and particularly in the most primitive, long-term repopulating cell population. Here we report that combining electroporation o...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Biotechnol
मुख्य लेखकों: Wang, Jianbin, Exline, Colin M., DeClercq, Joshua J., Llewellyn, G. Nicholas, Hayward, Samuel B., Li, Patrick Wai-Lun, Shivak, David A., Surosky, Richard T., Gregory, Philip D., Holmes, Michael C., Cannon, Paula M
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842001/
https://ncbi.nlm.nih.gov/pubmed/26551060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3408
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