Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases

The HIV-1 coreceptor CCR5 is a validated target for HIV/AIDS therapy. The apparent elimination of HIV-1 in a patient treated with an allogeneic stem cell transplant homozygous for a naturally occurring CCR5 deletion mutation (CCR5(Δ32/Δ32)) supports the concept that a single dose of HIV-resistant he...

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Main Authors: Li, Lijing, Krymskaya, Ludmila, Wang, Jianbin, Henley, Jill, Rao, Anitha, Cao, Lan-Feng, Tran, Chy-Anh, Torres-Coronado, Monica, Gardner, Agnes, Gonzalez, Nancy, Kim, Kenneth, Liu, Pei-Qi, Hofer, Ursula, Lopez, Evan, Gregory, Philip D, Liu, Qing, Holmes, Michael C, Cannon, Paula M, Zaia, John A, DiGiusto, David L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677314/
https://ncbi.nlm.nih.gov/pubmed/23587921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.65
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