Pre-clinical Modeling of CCR5 Knockout in Human Hematopoietic Stem Cells by Zinc Finger Nucleases Using Humanized Mice

Genetic strategies to block expression of CCR5, the major co-receptor of human immunodeficiency virus type 1 (HIV-1), are being developed as anti-HIV therapies. For example, human hematopoietic stem/precursor cells (HSPC) can be modified by the transient expression of CCR5-targeted zinc finger nucle...

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Bibliographische Detailangaben
Hauptverfasser: Hofer, Ursula, Henley, Jill E., Exline, Colin M., Mulhern, Orla, Lopez, Evan, Cannon, Paula M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807977/
https://ncbi.nlm.nih.gov/pubmed/24151324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit382
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