RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases

Bloom (BLM) and Werner (WRN) syndrome proteins are members of the RecQ family of SF2 DNA helicases. In this paper, we show that restricting the rotational DNA backbone flexibility, by introducing vinylphosphonate internucleotide linkages in the translocating DNA strand, inhibits efficient duplex unw...

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發表在:Nucleic Acids Res
Main Authors: Garcia, Patrick L., Bradley, Glyn, Hayes, Christopher J., Krintel, Sussie, Soultanas, Panos, Janscak, Pavel
格式: Artigo
語言:Inglês
出版: Oxford University Press 2004
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在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC484189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15256542/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh709
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