RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases

Bloom (BLM) and Werner (WRN) syndrome proteins are members of the RecQ family of SF2 DNA helicases. In this paper, we show that restricting the rotational DNA backbone flexibility, by introducing vinylphosphonate internucleotide linkages in the translocating DNA strand, inhibits efficient duplex unw...

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Bibliografski detalji

Izdano u:	Nucleic Acids Res
Glavni autori:	Garcia, Patrick L., Bradley, Glyn, Hayes, Christopher J., Krintel, Sussie, Soultanas, Panos, Janscak, Pavel
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2004
Teme:	Articles
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC484189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15256542/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh709
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