BLM SUMOylation regulates ssDNA accumulation at stalled replication forks

Polymerase stalling results in uncoupling of DNA polymerase and the replicative helicase, which generates single-stranded DNA (ssDNA). After stalling, RAD51 accumulates at stalled replication forks to stabilize the fork and to repair by homologous recombination (HR) double-strand breaks (DSBs) that...

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Autors principals:	Karen J Ouyang, Michael J Matunis, Mary K Yagle, Nathan A Ellis
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2013-09-01
Col·lecció:	Frontiers in Genetics
Matèries:	Homologous Recombination Bloom’s syndrome DNA repair foci RecQ DNA helicases replication fork stability
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00167/full
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