Zoledronate upregulates MMP-9 and -13 in rat vascular smooth muscle cells by inducing oxidative stress

BACKGROUND: Bisphosphonates, including zoledronate, target osteoclasts and are widely used in the treatment of osteoporosis and other bone resorption diseases, despite side effects that include damaging the stomach epithelium. Beneficial and adverse effects on other organ systems, including the card...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Arun, Mehmet Zuhuri, Reel, Buket, Sala-Newby, Graciela B, Bond, Mark, Tsaousi, Aikaterini, Maskell, Perry, Newby, Andrew C
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841407/
https://ncbi.nlm.nih.gov/pubmed/27143852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S103124
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