Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate

BACKGROUND AND PURPOSE: To determine whether there is an association between vascular NADPH oxidase (NOX), superoxide, the small GTPase Rac(1) and PDE type 5 (PDE5) in human vascular smooth muscle cell (hVSMCs). EXPERIMENTAL APPROACH: hVSMCs were incubated with xanthine–xanthine oxidase (X-XO; a sup...

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Detalhes bibliográficos
Main Authors: Muzaffar, S, Shukla, N, Bond, M, Sala-Newby, G B, Newby, A C, Angelini, G D, Jeremy, J Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597240/
https://ncbi.nlm.nih.gov/pubmed/18660830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.300
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