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Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase
1. Prednisolone, a potent anti-inflammatory drug, has proved ineffective in treating acute respiratory distress syndrome (ARDS). ARDS is associated with superoxide (O(2)(•−)) generation, which negates nitric oxide (NO). NO also downregulates NADPH oxidase and inhibits O(2)(•−) formation. A possible...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1576183/ https://ncbi.nlm.nih.gov/pubmed/15852033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706235 |
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