Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase

1. Prednisolone, a potent anti-inflammatory drug, has proved ineffective in treating acute respiratory distress syndrome (ARDS). ARDS is associated with superoxide (O(2)(•−)) generation, which negates nitric oxide (NO). NO also downregulates NADPH oxidase and inhibits O(2)(•−) formation. A possible...

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Bibliographic Details
Main Authors: Muzaffar, Saima, Shukla, Nilima, Angelini, Gianni D, Jeremy, Jamie Y
Format: Artigo
Language:Inglês
Published: 2005
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576183/
https://ncbi.nlm.nih.gov/pubmed/15852033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706235
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