Structural characterization of NRAS isoform 5

It was recently discovered that the NRAS isoform 5 (20 amino acids) is expressed in melanoma and results in a more aggressive cell phenotype. This novel isoform is responsible for increased phosphorylation of downstream targets such as AKT, MEK, and ERK as well as increased cellular proliferation. T...

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Bibliografiske detaljer
Udgivet i:Protein Sci
Main Authors: Markowitz, Joseph, Mal, Tapas K., Yuan, Chunhua, Courtney, Nicholas B., Patel, Mitra, Stiff, Andrew R., Blachly, James, Walker, Christopher, Eisfeld, Ann‐Kathrin, de la Chapelle, Albert, Carson, William E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Protein Structure Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838646/
https://ncbi.nlm.nih.gov/pubmed/26947772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2916
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