Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

Fluoroquinolones form drug-topoisomerase-DNA complexes that rapidly block transcription and replication. Crystallographic and biochemical studies show that quinolone binding involves a water/metal-ion bridge between the quinolone C3-C4 keto-acid and amino acids in helix-4 of the target proteins, Gyr...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Malik, Muhammad, Mustaev, Arkady, Schwanz, Heidi A., Luan, Gan, Shah, Nirali, Oppegard, Lisa M., de Souza, Ernane C., Hiasa, Hiroshi, Zhao, Xilin, Kerns, Robert J., Drlica, Karl
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838383/
https://ncbi.nlm.nih.gov/pubmed/26984528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw161
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