The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

H2 relaxin activates the relaxin family peptide receptor-1 (RXFP1), a class A G-protein coupled receptor, by a poorly understood mechanism. The ectodomain of RXFP1 comprises an N-terminal LDLa module, essential for activation, tethered to a leucine-rich repeat (LRR) domain by a 32-residue linker. H2...

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Udgivet i:Nat Commun
Main Authors: Sethi, Ashish, Bruell, Shoni, Patil, Nitin, Hossain, Mohammed Akhter, Scott, Daniel J., Petrie, Emma J., Bathgate, Ross A. D., Gooley, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837482/
https://ncbi.nlm.nih.gov/pubmed/27088579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11344
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