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Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD sites, which reorientates the N-terminal LDLa module to act...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Hoare, Bradley L., Bruell, Shoni, Sethi, Ashish, Gooley, Paul R., Lew, Michael J., Hossain, Mohammed A., Inoue, Asuka, Scott, Daniel J., Bathgate, Ross A.D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309025/
https://ncbi.nlm.nih.gov/pubmed/30594862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.12.004
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