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The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
H2 relaxin activates the relaxin family peptide receptor-1 (RXFP1), a class A G-protein coupled receptor, by a poorly understood mechanism. The ectodomain of RXFP1 comprises an N-terminal LDLa module, essential for activation, tethered to a leucine-rich repeat (LRR) domain by a 32-residue linker. H2...
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Yayımlandı: | Nat Commun |
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Asıl Yazarlar: | , , , , , , , |
Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4837482/ https://ncbi.nlm.nih.gov/pubmed/27088579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11344 |
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