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Optimal Hydrogen-Bond Surrogate for α-Helices
Substitution of a main chain i→i+4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize -helices in diverse peptide sequences.
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| Publicat a: | Chem Commun (Camb) |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836946/ https://ncbi.nlm.nih.gov/pubmed/27046675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc01104g |
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