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Synthesis of Hydrogen-Bond Surrogate α-helices as Inhibitors of Protein-Protein Interactions
The α-helix is a prevalent secondary structure in proteins and critical in mediating protein-protein interactions (PPIs). Peptide mimetics that adopt stable helices have become powerful tools for the modulation of PPIs in vitro and in vivo. Hydrogen-bond surrogate (HBS) α-helices utilize a covalent...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109691/ https://ncbi.nlm.nih.gov/pubmed/24903885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470559277.ch130202 |
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