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Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices
Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target it...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412876/ https://ncbi.nlm.nih.gov/pubmed/21952530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc14730g |
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