Wird geladen...

Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target it...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mahon, Andrew B., Arora, Paramjit S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412876/
https://ncbi.nlm.nih.gov/pubmed/21952530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc14730g
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!