Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis

The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and triggers tyrosine kinase-dependent signaling, which down-regulates Kv1.3 current...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Martínez-Mármol, Ramón, Comes, Núria, Styrczewska, Katarzyna, Pérez-Verdaguer, Mireia, Vicente, Rubén, Pujadas, Lluís, Soriano, Eduardo, Sorkin, Alexander, Felipe, Antonio
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836834/
https://ncbi.nlm.nih.gov/pubmed/26542799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2082-0
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