Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition of class I histone deacetylases (HDACs), a group of chromatin remodeling enzymes...

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Библиографические подробности
Опубликовано в: :Sci Signal
Главные авторы: Morales, Cyndi R., Li, Dan L., Pedrozo, Zully, May, Herman I., Jiang, Nan, Kyrychenko, Viktoriia, Cho, Geoffrey, Kim, Soo Young, Wang, Zhao V., Rotter, David, Rothermel, Beverly A., Schneider, Jay W., Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836394/
https://ncbi.nlm.nih.gov/pubmed/27048565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad5736
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