Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

Histone deacetylases (HDACs) regulate cardiac plasticity; however, their molecular targets are unknown. As autophagy contributes to pathological cardiac remodeling, we hypothesized that HDAC inhibitors target autophagy. The prototypical HDAC inhibitor (HDACi), trichostatin A (TSA), attenuated both l...

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Detalhes bibliográficos
Main Authors: Cao, Dian J., Wang, Zhao V., Battiprolu, Pavan K., Jiang, Nan, Morales, Cyndi R., Kong, Yongli, Rothermel, Beverly A., Gillette, Thomas G., Hill, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053983/
https://ncbi.nlm.nih.gov/pubmed/21367693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015081108
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