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Transforming growth factor-β1 and diabetic nephropathy

Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreas...

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Bibliografske podrobnosti
izdano v:Am J Physiol Renal Physiol
Main Authors: Chang, Albert S., Hathaway, Catherine K., Smithies, Oliver, Kakoki, Masao
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835922/
https://ncbi.nlm.nih.gov/pubmed/26719364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00502.2015
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