High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy

Human genome-wide association studies have demonstrated that polymorphisms in the engulfment and cell motility protein 1 gene (ELMO1) are strongly associated with susceptibility to diabetic nephropathy. However, proof of causation is lacking. To test whether modest changes in its expression alter th...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Hathaway, Catherine K., Chang, Albert S., Grant, Ruriko, Kim, Hyung-Suk, Madden, Victoria J., Bagnell, C. Robert, Jennette, J. Charles, Smithies, Oliver, Kakoki, Masao
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776516/
https://ncbi.nlm.nih.gov/pubmed/26858454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600511113
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